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apalutamide will reduce the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with prescription drugs which might be CYP3A4 substrates may result in reduce exposure to these remedies.posaconazole will boost the stage or e